Biology and Molecular Biology

Science Hall 108     (973) 655-7164

molinac@mail.montclair.edu

Courses Taught

BIOL 230 Cell and Molecular Biology

BIOL 435 Experimental Molecular Biology

BIOL 486 Selected Topics in Biology

BIOL 548 Molecular Biology II

BIOL 549 Topics in Developmental Biology

Publications

1. Candelas, G.C., Ortiz, A., and Molina, C.A.: The Cylindrical or Tubiliform Glands of Nephila Clavipes. The Journal of Experimental Zoology 237, 281-285, (1986).

2. Molina, C.A. and Ashendel, C.L.: Tumor Promoter 12-0-Tetradecanoylphorbol-13-Acetate And Sn-1, 2-Dioctanoylglycerol Increase The Phosphorylation of Protein Kinase C In Cells. Cancer Research 51, 4624-4630, (1991).

3. Molina, C.A., Foulkes, N.S., Lalli, E., and Sassone-Corsi, P.: Inducibility And Negative Autoregulation of CREM: An Alternative Promoter Directs The Expression of ICER, An Early Response Repressor. Cell 75, 875-886, (1993).

4. Stehle, J.H., Foulkes, N.S., Molina, C.A., Simonneaux, V., Pevet, P., and Sassone-Corsi, P.: Adrenergic Signals Direct Rhythmic Expression of Transcriptional Repressor CREM In the Pineal Gland. Nature 365, 314-320, (1993).

5. Delmas, V., Molina, C.A., Lalli, E., de Groot, R., Foulkes, N.S., Masquilier, D., and Sassone-Corsi, P.: Complexity And Versatility of The Transcription Response To cAMP Reviews of Physiology, Biochemistry and Pharmacology, Springer-Verlag 124, 2-28, (1993).

6. Masquilier, D., Laoide, B.M., Delmas, V., de Groot, R., Foulkes, N.S., Benusiglio, E., Molina, C.A., Schlotter, F., and Sassone-Corsi, P.: Transcription Factor CREM: A Key Element of The Nuclear Response To cAMP.  New Development in Lipid-Protein Interactions and Receptor Function, NATO ASI Series, Eds. K.W.A. Wirtz, L. Packer, J.A. Gustafsson, A.E. Evangelopoulos and J.P. Changeux, Plenum Press 246, 139-152, (1993).

7. Lalli, E., Lee, J.S., Masquilier, D., Schlotter, F., Foulkes, N.S., Molina, C.A., and Sassone-Corsi, P.: Nuclear Response To Cyclic AMP: Central Role of Transcription Factor Cyclic-AMP-Responsive-Element Modulator. Biochemical Society Transactions 21, 912-917, (1993).

8. Desdouets, C., Matesic, G., Molina, C.A., Foulkes, N.S., Sassone-Corsi, P., Brechot, C. and Sobczak-Thepot, J.  Cell Cycle Regulation of Cyclin A Expression by the Cyclic AMP-Responsive Transcription Factors CREB and CREM.  Mol. Cell. Biol. 15:3301-3309, (1995).

9. Lee, J.S., Lalli, E., Masquilier, D., Schlotter, F., Molina, C.A., Foulkes, N.S. and Sassone-Corsi, P. CREM. A Master-Switch In The Nuclear Response to cAMP.  In: Inducible Gene Expression. Ed. P.A. Baeuerle, Birkhauser, Boston 2, 1-38, 1995.

10. Lamas, M., Molina, C.A., Foulkes, N.S., Jansen, E. and Sassone-Corsi, P. Ectopic ICER Expression in Pituitary Corticotroph AtT20 Cells: Effects on Morphology, Cell Cycle and Hormonal Production. Mol. Endo. 11:1425-1434 (1997).

11.     Molina, C.A. ICER and the nuclear response to cAMP. In: Cell Death in Reproductive Physiology. Ed. Springer-Verlag, New York 15, 182-193, 1997.

12.     Razavi, R., Ramos, J.C., Yehia, G., Schlotter, F. and Molina, C.A. ICER-IIg is a Tumor Suppressor that Mediates the Antiproliferative Activity of cAMP. Oncogene 17:3015-3019 (1998).

13.     Maronde, E., Pfeffer, M., Olcese, J., Molina, C.A., Schlotter, F., Dehghani, Korf, H.W. and Stehle, J.H. Transcription Factors in Neuroendocrine Regulation: Rhythmic Changes in pCREB and ICER Levels Frame Melatonin Synthesis. J. Neuroscience 19:3326-3336 (1999).

14.     Pfeffer, M., Maronde, E., Molina, C.A., Korf H.W.- and Jörg H. Stehle. Inducible Cyclic AMP Early Repressor Protein in Rat Pinealocytes: A Highly Sensitive Natural Reporter for Regulated Gene Transcription. Molecular. Pharmacology 56:279-289 (1999).

15. Santiago, F., Clark, E., Chong, S., Molina, C.A., Mozafari, F., Mahieux, R., Fujii, M., Azimi, N., and Kashanchi F. Transcriptional Up-regulation of Cyclin D2 Gene and Acquisition of New CDK Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells. J. Virology 73:9917-9927 (1999).

16. Luteal Progesterone Relates to Histological Endometrial Maturation in Fertile Women. Santoro, N., Goldsmith, L.T., Heller, D., Illsley, N., McGovern, P., Molina, C.A., Peters, S., Skurnick, J.H., Forst, C., and Weiss, G. Journal of Clinical Endocrinology & Metabolism. 85:4207-4211 (2000).

17. Cloning of Human Preprotachykin-I Promoter and the Role of Cyclic Adenosine 5’-Monophosphate Response Elements in Its Expression by IL-1 Stem Cell Factor. Qian, J., Yehia, G., Molina C.A., Fernandes, A., Donnelly, R.J., Anjaria, D.J. Gascon, P., and Rameshwar, P. J. Immunology 166:2553-2561 (2001).

18. The Expression of Inducible cAMP Early Repressor (ICER) is Altered in Prostate Cancer Cells and Reverses the Transformed Phenotype of the LNCaP Prostate Tumor cell line. Yehia, G., Razavi, R., Memin, E., Schlotter, F., and Molina, C.A. Cancer Research 61: 6055-6059 (2001).

19. MAP Kinase Phosphorylates and Targets Inducible cAMP Early Repressor to Ubiquitin-Mediated Destruction. Yehia, G., Schlotter, F., Razavi, R., Alessandrini, A. and Molina, C.A. J. Biol. Chem. 276: 35272-35279 (2001).

20. Molina, C.A. Inducible cAMP Early Repressor. In: Encyclopedia of Molecular Medicine, Thomas E. Creighton (ed), John Wiley & Sons, 3:1739-1741, 2002.

21. Ratnakar,P.V.A.L., Yehia, G., Mémin, E., and Molina, C.A. ICER: A putative tumor suppressor. In: Research Advances in Cancer. Global Research Network Publication, INDIA 2, 285-295, (2002).

22. Evidence for a Regulatory Role of Inducible Cyclic Adenosine 3'5'-Monophosphate Early Repressor (ICER) in Protein Kinase A Enhancement of Vitamin D Receptor Expression and Modulation of Hormone Action. Michel Huening, M., Yehia, G., Molina, C.A., and Christakos, S. Mol. Endo. 16: 2052-2064 (2002).

23. Memin, E., Yehia, G., Razavi, R. and Molina, C.A. ICER Reverses Tumorigenesis of Rat Prostate Tumor Cells without Affecting Cell Growth. Prostate 53: 225-231 (2002).

24. Nervina, J.M. Tetradis, S., Huang, Y.-F., Harrison D., Molina, C.A., and Kream, B.E. Expression of Inducible cAMP Early repressor is coupled to the cAMP-protein kinase A signaling pathway in osteoblasts. Bone, 32: 483-490 (2003).

25. Yamamoto, S., Hong, C., Zablocki, D., Liu, J., Kim, S-J., Soler, S., Yang, G., Yehia, G., Molina, C.A., Vatner, S.F., and Sadoshima, J. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J. Clin Invest. 111: 1463-1474 (2003).

26. Tomita, H., Nazmy, M., Kajimoto, K., Yehia, G., Molina, C.A., and Sadoshima, J., Inducible cAMP early repressor (ICER) is a negative feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to b-adrenergic receptor stimulation. Circ Res. 93:12-22 (2003).

27. Huang, H.F.S., Wang, S., Molina, C.A., Ottenweller, J.E. Preservation of spermatogenesis in spinal cord injured rats with exogenous testosterone. Relationship with serum testosterone levels and cellular localization of cAMP responsive element modulator. Journal of Andrology 25:95-103, (2004).

28. Kell, C.A., Dehghani, F., Wicht, H., Molina, C.A., Korf, H.-W., and Stehle, J.H. Distribution of transcription factor ICER (inhibitory cyclicAMP early repressor) in rodent brain and pituitary. Journal of Comparative Neurology 478:379-394, (2004).

29. Ding, B., Abe, J., Wei, H., Huang, Q., Walsh, R.A., Molina C.A., Zhao, A., Sadoshima , J., Blaxall, B.C., Berk, B.C., and Yan, C. Functional Role of Phosphodiesterase 3 in cardiomyocyte apoptosis Implication in Heart Failure. Circulation 93:12-22 (2005).

30. Ding, B., Abe, J., Wei, H., Che W., Aizawa, T., Molina C.A., Sadoshima , J., Blaxall, B.C., Berk, B.C., and Yan, C. A Positive Feedback Loop of Phosphodiesterase 3 (PDE3) and Inducible cAMP Early Repressor (ICER) Leads to Persistent ICER Induction and Cardiomyocyte Apoptosis. PNAS 102:14771-14776 (2005).

31.     Muniz, L. Yehia, G., Pillarisetty, R., Memin, E. and Molina, C.A. Transcriptional Regulation of Cyclin D2 by the PKA Pathway and Inducible cAMP Early Repressor (ICER) in Granulosa Cells. Biology of Reproduction 75:279-288 (2006).

32. Chen, Y., Ding, B., Shishido, T., Woo, C-H., Itoh, S., Jeon, K-I., Liu, W., Xu, H., McClain, C., Molina, C.A., Blaxall, B.C., Abe J. Activation of ERK5 reduces cardiac apoptosis and dysfunction via inhibition of a PDE3A-ICER feedback loop. Circulation Research 100:510-519 (2007).

33. Harzenetter, M.D., Novotny, A.R., Gais, P., Molina, C.A., Altmayr, F., and Holzmann, B. Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER. The Journal of Immunology 179:607-615 (2007).

34. Corcoran, K.E., Malhotra, A., Molina, C.A. and Rameshwar, P. Stromal-derived factor-1α induces a non-canonical pathway to activate endocrine-linked Tac1 gene in non-tumorigenic breast cells. Journal of Molecular Endocrinology 40:113-123 (2008).